Wang, Jian-Ta published the artcileNovel berberine-based derivatives with potent hypoglycemic activity, Related Products of isoquinoline, the main research area is berberine derivative preparation mol docking hypoglycemic diabetes type two; AMP-activated protein kinase; Berberine; Hypoglycemic activity; Synthesis; Type 2 diabetes.
Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound I exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, resp. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway.
Bioorganic & Medicinal Chemistry Letters published new progress about AMP-activated protein kinase activators. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem