Zhao, Yunbo published the artcileB(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is diazoacetate benzotriazole pentafluorophenyl borane catalyst regioselective alkylation; alkyl benzotriazole preparation.
Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes was described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol was successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.
Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylation catalysts, regioselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem