Ni, Nanting’s team published research in Bioorganic & Medicinal Chemistry in 20 | CAS: 371766-08-4

Bioorganic & Medicinal Chemistry published new progress about 371766-08-4. 371766-08-4 belongs to isoquinoline, auxiliary class Isoquinoline,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Isoquinolin-5-ylboronic acid, and the molecular formula is C9H8BNO2, Category: isoquinoline.

Ni, Nanting published the artcileProbing the general time scale question of boronic acid binding with sugars in aqueous solution at physiological pH, Category: isoquinoline, the publication is Bioorganic & Medicinal Chemistry (2012), 20(9), 2957-2961, database is CAplus and MEDLINE.

The boronic acid group is widely used in chemosensor design due to its ability to reversibly bind diol-containing compounds The thermodn. properties of the boronic acid-diol binding process have been investigated extensively. However, there are few studies of the kinetic properties of such binding processes. In this report, stopped-flow method was used for the first time to study the kinetic properties of the binding between three model arylboronic acids, 4-, 5-, and 8-isoquinolinylboronic acids, and various sugars. With all the boronic acid-diol pairs examined, reactions were complete within seconds. The kon values with various sugars follow the order of D-fructose > D-tagatose > D-mannose > D-glucose. This trend tracks the thermodn. binding affinities for these sugars and demonstrates that the ‘on’ rate is the key factor determining the binding constant

Bioorganic & Medicinal Chemistry published new progress about 371766-08-4. 371766-08-4 belongs to isoquinoline, auxiliary class Isoquinoline,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Isoquinolin-5-ylboronic acid, and the molecular formula is C9H8BNO2, Category: isoquinoline.

Referemce:
https://en.wikipedia.org/wiki/Isoquinoline,
Isoquinoline | C9H7N – PubChem