Visseq, Alexia published the artcilePyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia, Synthetic Route of 371766-08-4, the publication is European Journal of Medicinal Chemistry (2020), 111917, database is CAplus and MEDLINE.
A series of 3,5-disubstituted pyridin-2(1H)-ones I [R = 1H-indol-4-yl, (1,1-biphenyl)-4-yl, 3-chlorophenyl, etc.] was designed, synthesized and evaluated in vivo toward a rat model of inflammatory mech. allodynia. The series rapidly and strongly prevented the development of mech. allodynia. The compound I (R = 2-bromophenyl (A)), a most active compound of the series, which was also able to quickly reverse neuropathic MA in rats, was founded. Next, when compound (A) was evaluated toward a panel of 50 protein kinases (PK) in order to identify its potential biol. target(s), it was found that compound (A) is a p38α MAPK inhibitor, a PK known to contribute to pain and hypersensitivity in animal models. 3,5-Disubstituted pyridin-2(1H)-ones I thus could represent a novel class of analgesic for the treatment of mech. allodynia.
European Journal of Medicinal Chemistry published new progress about 371766-08-4. 371766-08-4 belongs to isoquinoline, auxiliary class Isoquinoline,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Isoquinolin-5-ylboronic acid, and the molecular formula is C12H10O4S, Synthetic Route of 371766-08-4.
Referemce:
https://en.wikipedia.org/wiki/Isoquinoline,
Isoquinoline | C9H7N – PubChem