Reaction of malononitrile with some β-dicarbonyl compounds was written by Ducker, John W.;Gunter, Maxwell J.. And the article was included in Australian Journal of Chemistry in 1975.Application In Synthesis of 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile The following contents are mentioned in the article:
The reaction of β-keto esters and amides with NCCH2CN, in the presence of alcohol, proceeded through cycanocarbon acid and iminopyran intermediates to give the pyridones I [RR1 = (CH2)3, (CH2)4; R = Me, R1 = H; R2 = OEt, OMe, NHPh, NEt2, Me]. With β-diketones, in benzene solution, a similar reaction is accompanied by the formation of lactams II and benzene derivatives III (n = 1,2). This study involved multiple reactions and reactants, such as 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (cas: 52903-71-6Application In Synthesis of 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile).
1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (cas: 52903-71-6) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Application In Synthesis of 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem