Pansuriya, Ketan published the artcileTrimethylsilyl chloride catalyzed synthesis of fluoro substituted tetrahydropyrimidines: Molecular docking and antidiabetic studies, SDS of cas: 598-50-5, the main research area is tetrahydropyrimidine preparation antidiabetic docking; aldehyde ethyl acetoacetate urea Biginelli condensation trimethylsilyl chloride catalyst.
A novel series of tetrahydropyrimidine derivatives I [R1 = H, Me; R2 = H, Me] and II [R3 = NC, COOH, CO2Me, CO2Et] containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation. Various catalysts were employed in the reactions for yield increment but trimethylsilyl chloride gave the highest yield. Moreover, all synthesized mols. were checked for in vitro antidiabetic potential. In addition, mol. docking of these synthesized mols. was studied using barley alpha-amylase isoenzyme 1 (amy1) (1RPK). The result revealed that compounds I [R1 = R2 = H; R1 = R2 = Me] had a good inhibitory potential.
Chemical Data Collections published new progress about Antidiabetic agents. 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, SDS of cas: 598-50-5.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem