Sumrra, Sajjad H. published the artcileEfficient synthesis, characterization, and in vitro bactericidal studies of unsymmetrically substituted triazole-derived Schiff base ligand and its transition metal complexes, Synthetic Route of 1455-77-2, the main research area is unsym triazole Schiff base ligand transition metal preparation antibacterial; furanylethylideneamino triazolyliminophenol Schiff base preparation transition metal complexation; mol structural calculation furanylethylideneamino triazolyliminophenol Schiff base transition metal.
In the present research, novel unsym. substituted triazole-derived Schiff base ligand 2-[[[5-[[1-(5-methylfuran-2-yl)ethylidene]amino]-1H-1,2,4-triazol-3-yl]imino]methyl]phenol (L) has been synthesized by the reaction of 1,2,4-triazole-3,5-diamine with 2-hydroxybenzaldehyde and with 5-methyl-2-acetylfuran in an equimolar ratio. The synthesized ligand L was characterized by phys. methods (m.p., solubility, color) as well as by spectral techniques (IR, UV-Vis, 1H NMR, 13C NMR, and MS), elemental anal., and computational studies. Computational anal. further elucidated the structure, polarity, stability, and nature of the ligand. The bivalent(II), trivalent(III), and tetravalent(IV) transition metal complexes were formed by reacting Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), and Cr(III) metals as chloride and, VO(IV) as sulfate with Schiff base ligand L in 1:2 (M:L) molar ratio. Ligand was coordinated with the metal ions, VO via benzaldehyde-O and azomethine-N and with Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), and Cr(III) via benzaldehyde-O, azomethine-N, and triazole-N. The structure of the metal complexes was deduced by IR, conductance, magnetic moments, and elemental anal. Biol. evaluation of triazole-derived Schiff base ligand and its metal complexes was carried out against bacterial strains, Escherichia coli, Staphylococcus aureus, Neisseria gonorrhea, and Pseudomonas syringae. Copper complex showed the highest inhibition against all bacterial strains as compared to the free ligand and amongst other metal complexes. In vitro antibacterial studies thus concluded that the prepared ligand showed bioactivity which was enhanced upon chelation/coordination with the metal ions.
Monatshefte fuer Chemie published new progress about Antibacterial agents. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Synthetic Route of 1455-77-2.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem