Yamasaki, Ryu published the artcileConformational Switch of Benzanilide Derivative Induced by Acid; Effect of Pentafluorobenzoyl Group, Formula: C8H11NO, the main research area is benzanilide derivative conformational switch protonation pentafluorobenzoyl group effect.
Amide-based mol. switches had its limitation on structural diversities. In this work, we designed and synthesized a series of pentafluorobenzoyl-based benzanilide compounds The conformational ratio of these compounds in solution was correlated linearly with Hammett’s σp value of the substituent on the anilide ring, reflecting the repulsive interaction between the carbonyl group and the electron-rich aryl group. The addition of acid into the solution of 6, bearing pentafluorobenzoyl group, switched the stable amide conformation. In addition, the sizeable rotational barrier of 6 induced by the pentafluorobenzoyl moiety enabled us to monitor the conformational transition by means of 1H NMR spectroscopy.
Journal of Organic Chemistry published new progress about Activation enthalpy. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem