Mustafa, Rania published the artcileSynthesis of diatrizoic acid-modified LAPONITE nanodisks for CT imaging applications, Related Products of isoquinoline, the main research area is epithelial carcinoma diatrizoic acid.
We report a novel iodinated computed tomog. (CT) contrast agent, diatrizoic acid (DTA)-modified LAPONITE (LAP) nanodisks for X-ray CT imaging applications. In this study, LAP was first silanized with aminopropyldimethylethoxysilane to render the particles with amine groups (LM-NH2). Then, the LM-NH2 nanoparticles (NPs) were conjugated with DTA via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride coupling chem., followed by acetylation of the remaining amines of the LM-NH2-DTA NPs to improve their cytocompatibility. The formed LM-NHAc-DTA NPs were characterized via different techniques. The results of the cell viability assay reveal that the LM-NHAc-DTA NPs are cytocompatible in the given concentration range of 0.1-1.0 mg mL-1. The measurements of the X-ray attenuation coefficient demonstrate that the CT value of the LM-NHAc-DTA NPs is much higher than that of free DTA at the same iodine concentration Notably, the acetylated LM-NHAc-DTA NPs showed a high performance in CT imaging of the major organs (heart, liver, and bladder) and a tumor model in vivo after i.v. injection. The developed LM-NHAc-DTA NPs may hold great promise to be used as a contrast agent for different CT imaging applications.
RSC Advances published new progress about Acetylation. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem