Troxler, Thomas published the artcileDecahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists, SDS of cas: 1205-17-0, the main research area is isoquinoline decahydro piperazinylcarbonyl preparation somatostatin receptor antagonist.
Starting from non-peptidic sst1-selective somatostatin receptor antagonists, first compounds with mixed sst1/sst3 affinity were identified by directed structural modifications. Systematic optimization of these initial leads afforded novel, enantiomerically pure, highly potent and sst3-subtype selective somatostatin antagonists, e.g. I (R = piperonyl, 6-methoxypyridin-3-yl, 6-quinoxalinyl, etc.), based on a (4S,4aS,8aR)-decahydroisoquinoline-4-carboxylic acid core moiety. These compounds can efficiently be synthesized and show promising PK properties in rodents.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem