Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors was written by Chen, Ping;Norris, Derek;Haslow, Kristin D.;Murali Dhar, T. G.;Pitts, William J.;Watterson, Scott H.;Cheney, Daniel L.;Bassolino, Donna A.;Fleener, Catherine A.;Rouleau, Katherine A.;Hollenbaugh, Diane L.;Townsend, Robert M.;Barrish, Joel C.;Iwanowicz, Edwin J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Recommanded Product: 23707-37-1 This article mentions the following:
Screening of our inhouse compound collection led to the discovery of 5-bromo-6-aminoisoquinoline (I) as a weak inhibitor of IMPDH. Subsequent optimization of I afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, e.g., II, with single-digit nanomolar potency against the enzyme. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Recommanded Product: 23707-37-1).
Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Recommanded Product: 23707-37-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem