Versatile synthesis of 3,4-dihydroisoquinolin-1(2H)-one derivatives via intra-molecular Friedel-Crafts reaction with trifluoromethanesulfonic acid was written by Murashige, Ryo;Ohtsuka, Yoko;Sagisawa, Kazuki;Shiraishi, Mitsuru. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 22245-96-1 This article mentions the following:
Versatile intramol. Friedel-Crafts reaction of 1-(2-iso-cyanatoethyl)benzene derivatives was established by using trifluoromethanesulfonic acid as a catalyst and solvent. This methodol. was applied to the substrates with strong electron-withdrawing group. Furthermore, using the Friedel-Crafts product as a common synthetic intermediate, synthesis of several isoquinoline derivatives was also successful. In the experiment, the researchers used many compounds, for example, 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1Recommanded Product: 22245-96-1).
7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Recommanded Product: 22245-96-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem