Duvvuri, Muralikrishna et al. published their research in Biochemistry in 2005 | CAS: 23707-37-1

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Name: Isoquinolin-7-amine

A Chemical Strategy To Manipulate the Intracellular Localization of Drugs in Resistant Cancer Cells was written by Duvvuri, Muralikrishna;Konkar, Samidha;Funk, Ryan S.;Krise, Joanna M.;Krise, Jeffrey P.. And the article was included in Biochemistry in 2005.Name: Isoquinolin-7-amine This article mentions the following:

A number of multidrug-resistant (MDR) cancer cells have been shown to have acquired an increased capacity to sequester weakly basic anticancer drugs in their lysosomes relative to drug-sensitive counterparts. In this report the authors have comparatively evaluated the concentrations of the anticancer agent daunorubicin (DNR) in intracellular compartments of drug-sensitive and MDR HL-60 cell lines, both of which do not express common efflux transporters such as P-glycoprotein at the plasma membrane. Our results suggest that lysosomal sequestration plays a significant role in the emergence of MDR since it effectively limits the drug’s ability to interact with target mols. located in the nucleus. Using a series of weakly basic structural isomers with variable basicity, the authors illustrate that the magnitude of the pKa value correlates with the degree of lysosomal sequestration. Accordingly, a series of structurally modified forms of DNR with reduced basicity were synthesized, and their intracellular distribution was evaluated. Consistent with model compounds, derivatives of DNR with lowered pKa values showed visibly reduced lysosomal sequestration in two sep. MDR cell lines. Collectively, this work highlights the importance of understanding the intracellular localization of drugs and proposes a rational strategy to manipulate it. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Name: Isoquinolin-7-amine).

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Name: Isoquinolin-7-amine

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem