Metal-, photocatalyst-, and light-free late-stage C-H alkylation of N-heteroarenes with organotrimethylsilanes using persulfate as a stoichiometric oxidant was written by Dong, Jianyang;Wang, Xiaochen;Wang, Zhen;Song, Hongjian;Liu, Yuxiu;Wang, Qingmin. And the article was included in Organic Chemistry Frontiers in 2019.HPLC of Formula: 36034-54-5 This article mentions the following:
Benzylsilanes and heteroatom substituted silanes underwent homolytic cleavage to form C(sp3)-centered radicals that can participate in C-H alkylation reactions with N-heteroarenes under oxidative conditions has been reported. These reactions take place under mild conditions with persulfate as a stoichiometric oxidant and do not require a metal, a photocatalyst, light, or high temperature, making the reactions suitable for late-stage C-H alkylation of complex mols. The utility of the method was demonstrated by the preparation or functionalization of several structurally complex drugs and natural products. In the experiment, the researchers used many compounds, for example, 4-Methoxyisoquinoline (cas: 36034-54-5HPLC of Formula: 36034-54-5).
4-Methoxyisoquinoline (cas: 36034-54-5) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.HPLC of Formula: 36034-54-5
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem