Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase was written by Suto, M. J.;Turner, W. R.;Arundel-Suto, C. M.;Werbel, L. M.;Sebolt-Leopold. And the article was included in Anti-Cancer Drug Design in 1991.Safety of 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one This article mentions the following:
A series of dihydroisoquinolinones I(R = 5-, 6-, 7-, 8-OH, 5-, 6-, 7-OMe, 5-, 7-NO2, 5-, 7-NH2, H) and isoquinolinones II (R1 = H, OH, OMe, NO2, NH2), formally rigid analogs of 3-substituted benzamides, and a series of disubstituted benzamides III (R2 = H, Me; R3 = Me, Et, Pr, vinyl) were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the amide with respect to the substituent on the aromatic ring was critical for optimum inhibitory activity. Selected compounds were also evaluated for their ability to modify the radiation response of mammalian cells to ionizing radiation. A number of the 5-substituted I were very potent inhibitors of the enzyme, were able to enhance the lethal effects of ionizing radiation in mammalian cells, as measured by changes in the survival curve parameters Do and/or Dq. In the experiment, the researchers used many compounds, for example, 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1Safety of 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one).
7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Safety of 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem