Synthesis, chemistry and photochemical substitutions of 6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepin-11-ones was written by Girard, Yves;Atkinson, Joseph G.;Belanger, Patrice C.;Fuentes, Jose J.;Rokach, Joshua;Rooney, C. Stanley;Remy, David C.;Hunt, Cecilia A.. And the article was included in Journal of Organic Chemistry in 1983.Synthetic Route of C9H8N2O3 This article mentions the following:
Title pyrrolobenzazepinones, I (R = H, cyano, Br, NO2, CHO, CO2H, SOMe, SCF3, etc.; R1 = H, SO2F, Me, NH2, NHAc, Cl, cyano, CO2H, SCF3) were prepared as intermediates for potential central nervous system drugs. Substituents in the pyrrole ring of I were introduced by Friedel-Crafts cyclization of phenethylpyrrolecarboxylic acids II (R2 = OMe, OH, Cl) and by electrophilic substitution on the parent ketone I (R = R1 = H). Substituents in the benzene ring of I were introduced by Friedel-Crafts cyclization of (pyrrolylethyl)benzoic acids III (R1 = H, NO2, iodo). Novel and efficient photochem. reactions were discovered for the direct introduction of the cyano and CF3 groups into the pyrrole ring of I (R = R1 = H). The latter reaction was extended to yield a series of trifluoromethylated heterocycles. In the experiment, the researchers used many compounds, for example, 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1Synthetic Route of C9H8N2O3).
7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Synthetic Route of C9H8N2O3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem