Influence of substituents on basicity of isoquinolines was written by Zielinski, W.. And the article was included in Studies in Organic Chemistry (Amsterdam) in 1988.Computed Properties of C9H8N2 This article mentions the following:
The pKa values for 1,3-dimethylisoquinoline, 1-phenyl-3-methylisoquinoline and series of 5-, 6- and 7-substituted derivatives were determined in 50% aqueous MeOH by spectrophotometric method. The pKa values for 5-, 6-, and 7-substituted isoquinoline derivatives were correlated with Hammett σ constants In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Computed Properties of C9H8N2).
Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Computed Properties of C9H8N2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem