Cu2O/1-(2-methylhydrazine-1-carbonyl)-isoquinoline 2-oxide catalyzed C-N cross-coupling reaction in aqueous media was written by Xie, Jian-Wei;Yao, Zhen-Bin;Wang, Xiao-Chuang;Zhang, Jie. And the article was included in Tetrahedron in 2019.Formula: C10H7NO2 This article mentions the following:
An exptl. simple, efficient, and inexpensive catalyst system was developed for the N-arylation of imidazole, indole, pyrrole, alkyl alc. amines, and alkyl amines RNH2 (R = Bu, hexyl, octyl, benzyl, 4-hydroxyphenyl, 2-hydroxyethyl, 2-hydroxypropyl, 2-hydroxybutyl) with aryl iodides and bromides R1X (R1 = 3-methoxyphenyl, pyridin-2-yl, 1,3-benzodioxol-5-yl, etc.; X = Br, I). The reaction proceeds in water-ethanol media at 120°C for 12 h with Cu2O as the catalyst, 1-(2-methylhydrazine-1-carbonyl)-isoquinoline 2-oxide as the ligand, and NaOH as the base to generate a wide range of N-arylated products R1R2 (R2 = imidazol-1-yl, 1H-indol-1-yl, pyrrol-1-yl, hydroxyethylaminyl, butylaminyl, etc.) in moderate to excellent yields. Aqueous medium, ease of operation, and broad substrate scope give the process a benign environmental profile. In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Formula: C10H7NO2).
Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Formula: C10H7NO2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem