Metal-free decarboxylative acylation of isoquinolines using 伪-keto acids in water was written by Chaubey, Narendra R.;Singh, Krishna Nand. And the article was included in Tetrahedron Letters in 2017.Quality Control of 5-Nitroisoquinoline This article mentions the following:
An efficient method for acylation of isoquinolines such as isoquinoline, 4-bromoisoquinoline, 4-phenylisoquinoline, etc. has been developed using 伪-ketoacids RC(O)C(O)2H (R = Me, thiophen-2-yl, naphthalene-2-yl, etc.) under metal- and additive-free conditions in water. The protocol involves C(sp2)-H functionalization of isoquinolines providing an easy access to C1-benzoylated isoquinolines RC(O)R1 (R1 = 4-bromoisoquinolin-1-yl, 4-phenylisoquinolin-1-yl, 5-nitroisoquinolin-1-yl, etc.), which constitute the core structure of a number of biol. active compounds and serve as key intermediate in the synthesis of many alkaloids. In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9Quality Control of 5-Nitroisoquinoline).
5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Quality Control of 5-Nitroisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem