With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-11-2,6-Fluoroisoquinoline,as a common compound, the synthetic route is as follows.
7.49 g of 4-hydroxy-piperidine-1-carboxylic acid-tert-butylester were dissolved in 20 ml_ of dry dimethyl acetamide. 1.49 g of sodium hydride (60%) were added. Then a solution of 3.65 g of 6-fluoroisoquinoline (3) in dimethyl acetamide was added dropwise. The solution was heated at 80 0C for 2 hours, then the solvent was removed and the residue was taken up in dichloromethane. The organic layer was extracted twice with water and then with brine, dried over magnesium sulfate and evaporated to dryness. The crude product was purified by silica gel chromatography to yield 6.22 g of 4-(isoquinolin-6-yloxy)-piperidine-1-carboxylic acid-tert-butylester (7). Rt = 1.32 min (Method B). Detected mass: 329.1 (M+H+).
1075-11-2, The synthetic route of 1075-11-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/12421; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem