Downstream synthetic route of 105627-79-0

105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 4-(Isoquinoline-5-sulfonyl)-[1,4]diazepane-1-carboxylic acid tert-butyl esterTo a stirred suspension of isoquinoline-5-sulfonylchloride hydrochloride (3.00 g, 11.4 mmol) in anhydrous methylene chloride (100 mL) was added tert-butyl 1-homopiperazine carboxylate (3.00 g, 15.0 mmol) and triethylamine (4.36 g, 43.1 mmol). The mixture was stirred for 3 h, evaporated to dryness, mixed with a saturated solution of sodium bicarbonate (100 mL) and extracted with ethyl acetate (80 mL¡Á2). The combined extracts were dried, filtered and evaporated to give an oil (4.45 g, 100%). LCMS (+APCI) m/z 392 (M+H).

105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; Alcon Research, Ltd.; US7867999; (2011); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem