724422-42-8, 6-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,724422-42-8
A mixture of 6-bromo-2-methyl-3,4-dihydroisoquinolin-1-one (1 g, 0.00418 mol), bis(pinacolato)diboron (1.59 g, 0.00627 mol) and potassium acetate (1.2 g, 0.0125 mol) were dissolved in DMF (15 mL) and the mixture was degassed with nitrogen for 15 min. Then, a catalytic amount of PdCl2(dppf).CH2Cl2 (0.17 g, 0.0002 mol) was added and purging with nitrogen continued for 5 min. Then the mixture was heated at 80 C. for 2 h. The reaction was monitored by TLC and 1HNMR. After completion of reaction, the mixture was diluted with water (50 mL) and extracted with EtOAc (2*100 mL). The combined organic layer was washed with water (2*50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain a crude product, which was purified by chromatography using eluent 40% EtOAc in hexane to obtain 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1-one (890 mg) as a light yellow oil.
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Reference：
Patent; Medivation Technologies LLC; Pujala, Brahmam; Jangir, Ramniwas; Guguloth, Rambabu; Shinde, Bharat Uttam; Rai, Roopa; Pham, Son Minh; Bernales, Sebastian; Lindquist, Jeffrey; Guha, Mausumee; Kallem, Satyanarayana; Bhatt, Bhawana; Bhagwat, Vikas Ramdas; (162 pag.)US2018/51013; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem