HPLC of Formula: 67929-86-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles. Author is Ziedan, Noha I.; Stefanelli, Fabio; Fogli, Stefano; Westwell, Andrew D..
New indole-based 1,2,4-oxadiazoles I (R1 = Me, Ph, 4-ClC6H4; R2 = H, MeO, Cl, etc.; R3 = H, Me) have been designed and synthesized as potential pro-apoptotic antitumor agents, via the base-catalyzed condensation reaction between substituted amidoximes and indole esters. Evaluation of antiproliferative activity against the human cancer cell lines COLO 320 (colorectal) and MIA PACA-2 (pancreatic) revealed IC50 values in the low micromolar range. Selected compounds were able to trigger apoptosis in sensitive cell lines, for example via activation of caspase-3/7, demonstrating that indole-based oxadiazoles possess in vitro antitumor and pro-apoptotic activity.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem