The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-(5-Bromothiophen-2-yl)pyridine( cas:123784-07-6 ) is researched.Product Details of 123784-07-6.Laroche, Jenny; Beydoun, Kassem; Guerchais, Veronique; Doucet, Henri published the article 《Direct heteroarylation of 5-bromothiophen-2-ylpyridine and of 8-bromoquinoline via palladium-catalysed C-H bond activation: simpler access to heteroarylated nitrogen-based derivatives》 about this compound( cas:123784-07-6 ) in Catalysis Science & Technology. Keywords: heteroarylation bromothiophenylpyridine bromoquinoline palladium catalyst C H bond activation. Let’s learn more about this compound (cas:123784-07-6).
The palladium-catalyzed direct heteroarylation of the pyridyl-containing substrates, 2-(5-bromothiophen-2-yl)pyridine and 8-bromoquinoline, proceeds in moderate to high yields with a variety of heteroarenes in the presence of 1-2 mol% of a palladium catalyst. This approach allows the access to polyheteroaroms. which are interesting building blocks as (NC)-chelate ligands. The reaction proceeds regioselectively at the C5 position of thiophenes, thiazoles, furans or pyrroles and tolerates various substituents such as formyl, acetyl, ester, nitrile or chloro on the heteroarene. Therefore, this method allows a straightforward modulation of the electron d. distribution on such derivatives
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem