Al-Wabli, Reem I.; Zakaria, Azza S.; Attia, Mohamed I. published the article 《Synthesis, spectroscopic characterization and antimicrobial potential of certain new isatin-indole molecular hybrids》. Keywords: methoxyindolyl oxoindolinylidene carbohydrazide diastereoselective preparation antibacterial antifungal activity; 5-methoxyindole; antibacterial; antifungal; isatin.They researched the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ).Safety of Methyl 5-methoxyindole-2-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67929-86-6) here.
New isatin-indole mol. hybrids I (X = H, MeO, F, Cl, Br; R = H, Ph, PhCH2, etc.) were synthesized and characterized by various spectroscopic tools. The in-vitro antimicrobial potential of the prepared compounds I was assessed using diameter of the inhibition zone (DIZ) and min. inhibitory concentration (MIC) assays against a panel of Gram-neg. bacteria, Gram-pos. bacteria and fungi. Most of the synthesized compounds I showed weak activities against Gram-neg. bacteria while compounds I (X = Cl, Br; R = H) exhibited good activities against Gram-pos. bacteria. On the other hand, compound I (X = MeO; R = PhCH2) emerged as the most active compound towards Candida albicans (C. albicans), with an MIC value of 3.9 μg/mL and compound I (X = Br; R = PhCH2) as the most active congener towards Aspergillus niger (A. niger), with an MIC value of 15.6 μg/mL. Moreover, compound I (X = Cl; R = PhCH2) manifested the best anti-P. notatum effect, with an MIC value of 7.8 μg/mL, making it equipotent with compound I (X = Br; R = PhCH2).
If you want to learn more about this compound(Methyl 5-methoxyindole-2-carboxylate)Safety of Methyl 5-methoxyindole-2-carboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(67929-86-6).
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem