Category: isoquinoline. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-(5-Bromothiophen-2-yl)pyridine, is researched, Molecular C9H6BrNS, CAS is 123784-07-6, about Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides. Author is Lu, Changhui; Gu, Yang; Wu, Jiang; Gu, Yucheng; Shen, Qilong.
A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of halo-substituted heteroarenes, such as pyridines, pyrimidines, quinolines, thiophenes, benzofurans, etc., were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit. The reactions were conducted under mild conditions, and several common functional groups were tolerated. The current method represented the first general method for the site-specific incorporation of difluoromethyl moiety into heteroarenes.
There is still a lot of research devoted to this compound(SMILES：BrC1=CC=C(C2=NC=CC=C2)S1)Category: isoquinoline, and with the development of science, more effects of this compound(123784-07-6) can be discovered.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem