Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine, is researched, Molecular C37H33O4P, CAS is 147700-62-7, about Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)-H Carbamoylation.SDS of cas: 147700-62-7.
A general and user-friendly synthesis of β-lactams, e.g., I and II, is reported that makes use of Pd0-catalyzed carbamoylation of C(sp3)-H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C-H bonds, in contrast to previous methods based on C(sp3)-H activation. In addition, the feasibility of an enantioselective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free β-lactams and β-amino acids.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem