On June 11, 2021, Gu, Qiong; Xu, Jun; Fang, Yuying published a patent.Electric Literature of 74904-29-3 The title of the patent was Preparation of benzimidazole compounds for ferroptosis inhibitors. And the patent contained the following:
The present invention relates to preparation of (aryl)benzimidazole compounds for ferroptosis inhibitors. In particular, I and II [wherein, R1 is 4-methylpiperazin-1-yl, 4-methyl-1-piperidyl, 1-piperidyl, morpholino; R2 is morpholino, 1,3-benzodioxol-5-yl, 4-pyrimidin-2-ylpiperazin-1-yl, etc.; R is halogen, Me, alkoxy, alkynyloxy or hydroxy; X is C or N] were prepared The benzimidazole compound provided by the invention has better ferroptosis inhibiting activity by introducing a lipophilic group at the R1 position and introducing a specific group at the R2 position, the compound can be used as a lead compound for preventing and treating nervous system diseases such as stroke. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Electric Literature of 74904-29-3
The Article related to benzimidazole compound preparation ferroptosis inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 74904-29-3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem