Kurouchi, Hiroaki; Otani, Yuko; Ohwada, Tomohiko published an article in 2016, the title of the article was Facile synthesis of 5- to 7-membered benzolactam compounds via strongly facilitated electrophilic aromtic substitution reaction.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one And the article contains the following content:
Activation of aromatic ring-tethered carbamate compounds with trifluoromethanesulfonic acid to obtain benzolactams with 5- to 7-membered rings and examined the substrate scope and limitations of this activation method. In 5-membered ring formation, a halogen group on the aromatic ring did not greatly affect the reaction yield, but other electron-donating groups inhibited the cyclization reaction and various side-reactions occurred. In 7-membered ring formation, eletron-donating groups on aromatic ring promoted the cyclization reaction but cyclization of electron-deficient aromatic rings did not proceed well. The 6-membered ring formation reaction showed the greatest substrate generality. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
The Article related to aralkylcarbamoyloxy benzoate preparation triflic acid promoter electrophilic aromatic substitution, benzolactam preparation, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem