Vodnala, Nagaraju published the artcileLewis Acid-Promoted Typical Friedel-Crafts Reactions Using DMSO as a Carbon Source, Safety of 1,3-Dimethoxybenzene, the main research area is diarylmethane preparation; arene dimethyl sulfoxide Friedel Craft reaction Lewis acid catalyst.
A mild and efficient synthetic protocol for the synthesis of sym. and unsym. diarylmethanes (DAMs) R1CH2R2 (R1 = 4-methoxyphenyl, 2,4,6-trimethylphenyl, 1H-indol-3-yl, 4-hydroxy-2-oxo-2H-chromen-3-yl, etc.; R2 = 4-hydroxy-3,5-dimethylphenyl, 5-methylfuran-2-yl, 4-amino-3,5-bis(propan-2-yl)phenyl, etc.) was reported. Using DMSO as the C1 source and TMSOTf as the Lewis acid promoter, a series of functionalized sym. and unsym. DAMs was synthesized in high yields. Gratifyingly, DMSO plays a dual role as a solvent and a C1 source and can also be replaced with its deuterated counterpart, DMSO-d6, enabling the incorporation of the -CD2 moiety into the diarylmethane skeleton. The developed approach has been applied to a wide range of substrates having various functional groups, and this protocol has also been extended to the synthesis of an anti-breast cancer agent and an anticoagulant agent using common feedstock compounds In addition, the postulated mechanism has been explicitly demonstrated via control experiments
Journal of Organic Chemistry published new progress about Anticoagulants. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem