Kawajiri, Takahiro published the artcileChemoselective Nucleophilic Functionalizations of Aromatic Aldehydes and Acetals via Pyridinium Salt Intermediates, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is aldehyde aryl arene trialkylsilyl triflate bipyridyl chemoselective nucleophilic substitution; acetal aryl arene trialkylsilyl triflate bipyridyl chemoselective nucleophilic substitution; allylsilane aldehyde aryl trialkylsilyl triflate bipyridyl chemoselective nucleophilic substitution; ether benzyl silyl preparation.
The development of a novel chemoselective functionalization can diversify the strategy for synthesizing the target mols. The perfect chemoselectivity between aromatic and aliphatic aldehydes is difficult to achieve by the previous methods. The aromatic aldehyde-selective nucleophilic addition in the presence of aliphatic aldehydes was newly accomplished. Namely, the aromatic aldehyde-selective nucleophilic addition using arenes and allyl silanes proceeded in the presence of trialkylsilyl triflate and 2,2′-bipyridyl, while the aliphatic aldehydes completely remained unchanged. The reactive pyridinium-type salt intermediate derived from an aromatic aldehyde chemoselectively underwent the nucleophilic substitution. Moreover, the aromatic acetals as the protected aldehydes could be directly transformed into similar pyridinium salt intermediates, which reacted with various nucleophiles coexisting with the aliphatic aldehydes.
Journal of Organic Chemistry published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation) (benzyl). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem