Hirbawi, Nadia published the artcileHalogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents, Synthetic Route of 104-01-8, the main research area is alkyl halide preparation; alc alkyl Grignard reagent halogenation.
Herein, an example of Grignard reagents acting as halide nucleophiles to form alkyl iodides RI [R = 1-(4-methoxyphenyl)-5-phenylpentan-3-yl, 4-phenylbutan-2-yl, 4-(2H-1,3-benzodioxol-5-yl)butan-2-yl, etc.] and alkyl bromides R1Br [R1 = 3-[4-(3-methoxyphenyl)phenyl]propyl, 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl, 3-(4-bromophenyl)propyl, etc.] was reported. This work establishes that Grignard reagents can convert alkyl mesylates ROMs/R1OMs into alkyl halides RI/R1Br, as well as be employed in a one-pot halogenation reaction starting from alcs. ROH/R1OH, which proceed through mesylate intermediates. The halogenation reaction is confirmed to occur by an SN2 pathway with the inversion of configuration and is demonstrated to be efficient on a gram scale.
Journal of Organic Chemistry published new progress about Bromoalkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem