Zhou, Leijie published the artcilePhosphine-Catalyzed Asymmetric Tandem Isomerization/Annulation of Allyl Amines with Allenoates: Enantioselective Annulation of a Saturated C-N Bond, Computed Properties of 104-01-8, the main research area is pyrroline preparation enantioselective DFT; allylamine allenoate asym tandem isomerization heterocyclization chiral phosphine catalyst.
Under catalysis by chiral phosphine, an asym. isomerization/annulation cascade reaction of allylamines ArSO2NHCH2CH=CHC(O)OCH2CH3 (Ar = Ph, 4-nitrophenyl, 4-methylphenyl) with allenoates RCH=C=CHC(O)O2CH3 (R = Me, cyclopropyl, 4-methoxyphenyl, etc.) was realized. A wide range of γ-substituted allenoates were tolerated to afford chiral pyrroline derivatives I in high yields with excellent enantioselectivities. In the reaction, isomerization of readily available N-allylamines to reactive aliphatic imines through a 1,4-proton shift is a key step, which circumvents the isolation of highly unstable alkyl N-sulfonylimines.
Organic Letters published new progress about Allyl amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem