Pradhan, Suman published the artcileRegiodivergent Aromatic Electrophilic Substitution Using Nitrosoarenes in Hexafluoroisopropanol: A Gateway for Diarylamines and p-Iminoquinones Synthesis, Application of 1,3-Dimethoxybenzene, the main research area is diaryl amine iminoquinone regiodivergent preparation; arene nitrosoarene regiodivergent aromatic electrophilic substitution.
A metal-free aromatic electrophilic substitution reaction using nitrosoarenes as electrophiles in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) was reported. HFIP activates nitrosoarene toward the electrophilic C-H amination followed by a concomitant N-O bond cleavage to deliver diarylamines, e.g. I (R1 = H, Cl, I, CF3, R2 = H; R1 = H, R2 = Br, Me, EtO2C) from 1,3,5-trimethoxybenzene, without requiring any extra reagent or further treatment. The dual electrophilic nature of nitrosoarene permitted a switch-over of selectivity to C-H oxygenation furnishing dearomatized p-iminoquinones, such as II, following a unique mechanistic rationale of two consecutive [2,3] sigmatropic rearrangement in nitroso-chem.
Advanced Synthesis & Catalysis published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem