Ye, Zenghui published the artcileEnantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is functionalized hindered triazolopyridinone derivative enantioselective preparation; pyridyl hydrazide preparation electrochem oxidative rearrangement; carboxylic acid hydrazine pyridyl hydrazide preparation.
An electrochem. rearrangement for efficient synthesis of inaccessible triazolopyridinones I [R1 = H, Me, Ph, etc.; R2 = H, Me, F, etc., R3 = Et, OTBS, 2-thienyl, etc.; R1R2 = cyclpropyl, adamantan-1-yl, tetrahydrofuran-2-yl, etc.; R4 = H, 8-Cl, 6-COOEt, etc.] with diverse alkyl carboxylic acids as starting materials was reported. This enabled efficient preparation of more than 60 functionalized triazolopyridinones I under mild conditions in a sustainable manner. This method was evaluated for late stage modification of bioactive natural products, amino acids and pharmaceuticals, and it was further applied to decagram scale preparation of enantiopure triazolopyridinones. The control experiments supported a mechanism involving an oxidative cyclization and 1,2-carbon migration. This facile and scalable rearrangement demonstrated power of electrochem. synthesis to access otherwise-inaccessible triazolopyridinones and may find wide application in organic, material and medicinal chem.
Nature Communications published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem