Mahajan, Sheena published the artcileMalononitrile-activated synthesis and anti-cholinesterase activity of styrylquinoxalin-2(1H)-ones, Product Details of C9H10O3, the main research area is quinoline quinoxaline methyl diastereoselective condensation aryl aldehyde malononitrile activator; styryl quinoxalinone preparation anticholinesterase activity mol modeling; methyl quinoxalinone diastereoselective condensation aryl aldehyde malononitrile activator.
A base-free malononitrile activated condensation of 3-methyl-6-R1-quinoxalin-2(1H)-ones (3MQ) with aryl aldehydes RCHO (R = Ph, 4-ClC6H4, PhCH:CH, thiophen-2-yl, etc.; R1 = H, NO2) for synthesis of styrylquinoxalin-2(1H)-ones (SQs) (E)-I in excellent yields has been described. In this reaction, malononitrile activates the aldehyde via Knoevenagel condensation towards reaction with 3MQ and gets liberated during the course of reaction to yield the desired SQs (E)-I. The SQs (E)-I were evaluated for in vitro cholinesterase inhibition and (E)-I (R = 4-F-3-BrC6H3) was found to display a mixed type of inhibition of AChE, which was supported by mol. modeling studies. The procedure was successfully applied to the synthesis the analogous styrylquinoxalines and styrylquinolines. This study has led to the discovery of a new chemotype for cholinesterase inhibition which might be useful in finding a remedy for Alzheimer’s disease.
RSC Advances published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem