Zhao, Mingsheng published the artcileSynthesis, characterization, and DRAK2 inhibitory activities of hydroxyaurone derivatives, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is hydroxyaurone preparation DRAK2 inhibitor SAR.
Authors reported the synthesis of 25 derivatives of hydroxyaurone which were characterized by 1H NMR, 13C NMR, high resolution mass spectrum, and single crystal X-ray diffraction anal. Their activities on the death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) were evaluated by kinase detection kit at a dosage of 5μM. Most of the synthetic hydroxyaurones exhibited moderate to good inhibitory activities. The IC50 value ranged from 0.81 to 2.42μM when the structure of aurone’s B ring was kept unchanged and its A ring was substituted by hydroxyl groups. On the contrary, modification of the aurone’s B-ring with hydroxyl groups lead to the IC50 value ranging from 1.15 to 17.5μM. This indicates presence of hydroxyl group of the B ring is crucial for aurone’s DRAK2 kinase inhibitors. Therefore, hydroxyaurone may serve as a new possible lead compound for the discovery of DRAK2. Further pharmacol. investigations are underway and will be reported in due course.
Heterocycles published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem