Koli, Papita published the artcileStructure-Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer, Category: isoquinoline, the main research area is alkyl kojylmethane aryl preparation human antitumor SAR docking.
A series of (alkyl/aryl)kojylmethane (IKM) derivatives I [R = 4-HOC6H4, 2-pyrrolyl, 3-indolyl, etc.; R1 = n-Bu, Ph, 2-naphthyl, etc.] was synthesized using a multicomponent one-pot reaction under solvent-free condition using a heterogeneous catalyst. The synthesized compounds were screened against breast cancer cell lines MDA-MB-231, MCF7, and T47D. The structure-activity relationship revealed that IKM synthesized from aliphatic aldehydes were active against all three cell lines and showed IC50 value of 0.15μM-3.93μM. IKM synthesized from aromatic aldehydes having electron-donating groups specifically inhibited the proliferation of the MDA-MB-231 cell line. The effect of various substituted indoles was also studied and observed that compound I [R = 5-CN-indol-3-yl, R1 = Ph] synthesized from 5-cyanoindole, specifically inhibited T47D cell line proliferation. Compound I [R = 3-indolyl, R1 = n-heptyl] synthesized from kojic acid, indole and octanal was found to be most potent with IC50 values of 0.21, 0.15, and 3.45μM against MDA-MB-231, MCF7, and T47D, resp.
ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem