Levinn, Carolyn M. published the artcileN-Methylation of Self-Immolative Thiocarbamates Provides Insights into the Mechanism of Carbonyl Sulfide Release, Quality Control of 5961-59-1, the main research area is self immolative methylated thiocarbamate carbonyl sulfide release mechanism.
Hydrogen sulfide (H2S) is an important biomol., and self-immolative thiocarbamates have shown great promise as triggerable H2S donors with suitable analogous control compounds; however, thiocarbamates with electron-deficient payloads are less efficient H2S donors. We report here the synthesis and study of a series of N-methylated esterase-triggered thiocarbamates that block the postulated unproductive deprotonation-based pathway for these compounds The relative reaction profiles for H2S release across a series of electron-rich and electron-poor N-Me aniline payloads are examined exptl. and computationally. We show that thiocarbamate N-methylation does block some side reactivity and increases the H2S release profiles for electron-poor donors. Addnl., we show that isothiocyanate release is not a competitive pathway, and rather that the reduced efficiency of electron-poor donors is likely due to other side reactions.
Journal of Organic Chemistry published new progress about Decomposition kinetics (hydrogen sulfide formation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem