Jin, Jing-Hai published the artcileAsymmetric Synthesis of Spirooxindole β-lactams via Isothiourea-catalyzed Mannich/lactamization Reaction of Aryl Acetic Acids with Isatin-derived Ketimines, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is homobenzotetramisole catalyzed Mannich lactamization cascade carboxylic acid isatin ketimine; spiro oxindole beta lactam asym synthesis.
An efficient [2+2] annulation strategy featuring homobenzotetramisole (HBTM)-catalyzed Mannich/lactamization cascade reaction of carboxylic acids with isatin-derived ketimines has been disclosed [e.g., phenylacetic acid + ketimine I â?spirooxindole β-lactams II + III (96% overall, dr 88:12 resp., > 99% ee for II)]. This protocol affords a range of structurally diverse spirooxindole β-lactams bearing two vicinal stereogenic centers in good to high yields with good to excellent stereoselectivities.
Advanced Synthesis & Catalysis published new progress about [2+2] Cycloaddition reaction, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem