Yu, Wensheng published the artcileDiscovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation, Safety of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128168, database is CAplus and MEDLINE.
A series of unique macrocyclic HDACs 1, 2, and 3 selective inhibitors were identified with good enzymic activity and high selectivity over HDACs 6 and 8. These macrocyclic HDAC inhibitors used an Et ketone as the zinc-binding group. Compounds I and II stood out as leads due to their low double-digit nM EC50s in the 2C4 cell-based HIV latency reactivation assay. The PK profiles of these macrocyclic HDAC inhibitors still needed improvement.
Bioorganic & Medicinal Chemistry Letters published new progress about 1219130-56-9. 1219130-56-9 belongs to isoquinoline, auxiliary class Isoquinoline,Boronic acid and ester,Amide,Boronic Acids,Boronate Esters, name is 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one, and the molecular formula is C19H36BNO2Si, Safety of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one.
Referemce:
https://en.wikipedia.org/wiki/Isoquinoline,
Isoquinoline | C9H7N – PubChem