Synthesis of isoquinolines from indenes was written by Miller, R. Bryan;Frincke, James M.. And the article was included in Journal of Organic Chemistry in 1980.Reference of 75476-83-4 The following contents are mentioned in the article:
A general procedure for the preparation of Me, di-Me, NO2, Br, iodo, and di-MeO-substituted isoquinolines from the appropriately substituted indenes is described. Ozonolysis of the indenes followed by reductive workup gives intermediate homophthalaldehydes, which are treated with NH4OH to give the isoquinolines. This “one-pot”, three-step reaction sequence was applied to the formation of all of the mono-C-methyl-substituted isoquinolines in a regiospecific manner. The procedure is applicable to both electron-withdrawing and electron-donating substituents on the indene system. In this manner the 6- and 7-nitro-, -bromo-, and -iodoisoquinolines were prepared This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Reference of 75476-83-4).
7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Reference of 75476-83-4
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem