Model experiments on the construction of the ABE ring system of hetisine-type diterpene alkaloids was written by Van der Baan, J. L.;Bickelhaupt, F.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1975.Recommanded Product: 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile The following contents are mentioned in the article:
The cyanopyridinediols I-III were C-alkylated to the unsaturated imides IV-VII. The allyl derivatives VI and VII underwent Cope rearrangement to VIII and IX, resp. IX was transformed to the bromohydrin X, which, after protection of the HO group, was cyclized by base to XI. Removal of the protecting group and oxidation afforded ketone XII, which contains the ABE ring system of hetisine diterpene alkaloids. This study involved multiple reactions and reactants, such as 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (cas: 52903-71-6Recommanded Product: 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile).
1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (cas: 52903-71-6) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Recommanded Product: 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem