Schwarz, J. Luca published the artcile1,2-Amino Alcohols via Cr/Photoredox Dual-Catalyzed Addition of α-Amino Carbanion Equivalents to Carbonyls, SDS of cas: 1205-17-0, the main research area is amino alc preparation; aminomethylsilane carbonyl compound photoredox addition chromium catalyst photocatalyst.
Herein, we report the synthesis of protected 1,2-amino alcs. starting from carbonyl compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic system that allows the in situ generation of α-amino carbanion equivalent which act as nucleophiles. The unique nature of this reaction was demonstrated through the aminoalkylation of ketones and an acyl silane, classes of electrophiles that were previously unreactive toward addition of alkyl-Cr reagents. Overall, this reaction broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosynthetic strategy for the synthesis of 1,2-amino alcs.
Journal of the American Chemical Society published new progress about Addition reaction. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem