With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.129075-49-6,5-Methoxy-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
General procedure: To a suspension of NaH (0.11g, 4.5mmol) in DMF (10 mL), a solution in DMF (5 mL) of the appropriate 3,4-dihydroisoquinolin-1-one (1.8 mmol), was added in a dropwise manner, at 0 C under a stream of N2. After 15min, 1-bromo-3-chloropropane was added in a dropwise manner and the mixture was allowed to warm to room temperature and was kept under stirring for 30 min. After cooling to 0 C H2O was added and the solvent was removed under reduced pressure. The residue was taken up with water and extracted with AcOEt (3×10 mL). The organic layers were collected, dried over Na2SO4 and evaporated under reduced pressure. The crude residue was purified by column chromatography with CH2Cl2/AcOEt (1:1) as eluent., 129075-49-6
129075-49-6 5-Methoxy-3,4-dihydroisoquinolin-1(2H)-one 7385098, aisoquinoline compound, is more and more widely used in various fields.
Reference：
Article; Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M.; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 920 – 930;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem