The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ) is researched.Related Products of 67929-86-6.Di Giacomo, Barbara; Bedini, Annalida; Spadoni, Gilberto; Tarzia, Giorgio; Fraschini, Franco; Pannacci, Marilou; Lucini, Valeria published the article 《Synthesis and biological activity of new melatonin dimeric derivatives》 about this compound( cas:67929-86-6 ) in Bioorganic & Medicinal Chemistry. Keywords: melatonin dimeric derivative synthesis structure activity relationship receptor. Let’s learn more about this compound (cas:67929-86-6).
A new series of melatonin (MLT) dimers were obtained by linking together two melatonin units with a linear alkyl chain through the MLT acetamido group or through a C-2 carboxyalkyl function. The binding properties of these ligands were evaluated in in vivo experiments on cloned human MT1 and MT2 receptors expressed in NIH3T3 rat fibroblast cells. The class of 2-carboxyalkyl dimers was the most interesting one with compounds having good MT1/MT2 nanomolar affinity. The data obtained suggest that the spacer length is crucial for optimal interaction at both receptor subtypes as well as to determine functional activity of the resulting dimers.
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Reference:
Isoquinoline – Wikipedia,
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