On November 2, 2000, Mewshaw, Richard Eric; Meagher, Kristin Lynne published a patent.Computed Properties of 74904-29-3 The title of the patent was Preparation of tetrahydroisoquinolinylindole derivatives for the treatment of depression. And the patent contained the following:
The title compounds I [R1-R4 = H, halo, alkoxy, carboxamide; R5 = H, halo, CF3, CN, carbamide, alkoxy; X = (CH2)n, 4-6 membered carbocyclic ring, wherein n is an integer of 2 to 4], useful for the treatment of depression, were prepared E.g., 3-[(1,4-cis)-4-(7-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)cyclohexyl]-1H-indole-5-carbonitrile was prepared by reaction of 7-methoxy-1,2,3,4-tetrahydroisoquinoline (preparation given) with 4-(5-cyano-1H-3-indolyl)cyclohexanone in presence of sodium triacetoxyborohydride and acetic acid in CH2Cl2. I are active towards 5HT1A receptors and generally elevate serotonin levels by inhibiting 5-HT transport. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Computed Properties of 74904-29-3
The Article related to isoquinolinylindole preparation depression treatment, indole isoquinolinyl preparation depression treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Computed Properties of 74904-29-3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem