Sall, Daniel J.; Grunewald, Gary L. published an article in 1987, the title of the article was Inhibition of phenylethanolamine N-methyltransferase (PNMT) by aromatic hydroxy-substituted 1,2,3,4-tetrahydroisoquinolines. Further studies on the hydrophilic pocket of the aromatic ring binding region of the active site.Related Products of 74904-29-3 And the article contains the following content:
In a study directed toward characterizing the hydrophilic pocket within the aromatic ring binding region of the active site of phenylethanolamine N-methyltransferase (PNMT), 5-, 6-, 7-, and 8-hydroxy-1,2,3,4-tetrahydroisoquinoline were prepared and evaluated as substrates and inhibitors of PNMT. Thus, 2-MeOC6H4CH2CH2NHCO2Me was cyclized by polyphosphoric acid to give 8-methoxy-3,4-dihydroisoquinolin-1-one, which was reduced followed by demethylation to give 8-hydroxy-1,2,3,4-tetrahydroisoquinoline. In order to discern the necessity of an acidic hydrogen for interaction at this pocket the corresponding Me ethers were also evaluated. The enhanced affinity of 7-hydroxy-1,2,3,4-tetrahydroisoquinoline vs. tetrahydroisoquinoline itself indicates that a hydrophilic pocket exists off of carbon C7 in bound tetrahydroisoquinolines. The Me ethers of 5-, 6-, 7-, and 8-hydroxy-exo-2-aminobenzonorbornene and of 5- and 6-hydroxy-anti-9-aminobenzonorbornene were also evaluated for their activity as substrates and inhibitors for PNMT. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Related Products of 74904-29-3
The Article related to isoquinolinol tetrahydro preparation pnmt inhibition, phenylethanolamine methyltransferase inhibition, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Related Products of 74904-29-3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem