Chen, Zhiwei published the artcileManufacturing Process Development for Belzutifan, Part 3: Completing a Streamlined Through-Process with a Safe and Scalable Oxidation, HPLC of Formula: 151-10-0, the main research area is belzutifan preparation stability solubility.
The development of a modified Kornblum oxidation mediated by 2-picoline N-oxide for the synthesis of belzutifan that circumvented safety and stench problems associated with the original clin. supply route conditions was reported. A robust quench for the crude bromination stream with 1,3-dimethoxybenzene and 2,6-lutidine enabled a single-solvent through-process that avoided the isolation of a mutagenic intermediate and resulted in a significantly lower process mass intensity. A ternary-solvent, constant-volume distillation was then used to crystallize the ketone product directly from the reaction mixture
Organic Process Research & Development published new progress about Dioxolanes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem