Zhao, Feng published the artcileEnantioselective Synthesis of α-Aryl-β2-Amino-Esters by Cooperative Isothiourea and Broensted Acid Catalysis, Product Details of C9H10O3, the main research area is aminoarylpropanoate enantioselective preparation; enantioselective aminomethylation pentafluorophenyl arylacetate isothiourea hydrochloride catalyst; mechanism enantioselective aminomethylation pentafluorophenyl arylacetate acylisothiouronium intermediate; aminomethylation; cooperative catalysis; isothiourea; mechanistic studies; α-aryl-β-amino acid.
The synthesis of α-aryl-β2-amino esters such as (S)-Bn2NCH2CHPhCO2Me (Bn = PhCH2) through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Broensted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94% yield and 96:4 er), and the method was applied to the syntheses of (S)-venlafaxine hydrochloride and (S)-nakinadine B. Mechanistic studies are consistent with a C(1)-ammonium enolate pathway being followed rather than an alternative dynamic kinetic resolution process. Control studies indicate that (i) a linear effect between catalyst and product er is observed; (ii) an acyl ammonium ion can be used as a precatalyst; (iii) reversible isothiourea addition to an in situ generated iminium ion leads to an off-cycle intermediate that can be used as a productive precatalyst.
Angewandte Chemie, International Edition published new progress about Aminomethylation (stereoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem